李奇璋讲师

姓名：李奇璋

单位：淮北师范大学 生命科学学院

职称：讲师

学历：博士

E-mail：qizhang-li@hotmail.com；liqzh@chnu.edu.cn

研究方向：①中药资源创新与新药创制；②基于生物活性大分子的靶点发现和药理学研究；③药用真菌的合成生物学研究

个人简介：

淮北师范大学创新药物研发中心执行主任；中华中医药学会会员，中国微生物学会会员，湖北省生化学会理事，西安营养学会理事；公共营养师（一级）；基因健康管理师（中级）。 《中草药》青年编委；Appl Microbiol Biot、Front Plant Sci、Front Immunol、Front Nutr等杂志审稿人。主要从事中药资源创新与新药创制的研究工作。在学术期刊发表论文40余篇；以第一/通讯作者在Crit Rev Food Sci、Food Funct、Phytomedicine等TOP期刊发表SCI论文20篇；总引用880次，近五年引用529次（google scholar）；专利授权5项。CNKI中国优秀硕士学位论文全文数据库收录。主持安徽高校科学研究项目1项，湖北省教育厅科研计划项目1项，参与国家自然科学基金面上项目、上海市科委应用技术开发专项基金、上海市科委支撑项目、上海良友基团等多个项目。指导硕士研究生获得国家奖学金1人、校级优秀毕业生1人；指导本科生获得全国大学生生命科学竞赛(科学探究类)三等奖1次。

近五年科研论文：

(1)Yan Liu, Jiayi Yang, Zhijian Guo, Qizhang Li, Lida Zhang, Lingxia Zhao*, Xuanwei Zhou*. Immunomodulatory Effect of Cordyceps militaris Polysaccharide on RAW 264.7 Macrophages by Regulating MAPK Signaling Pathways. Molecules. 2024, 29(14): 3408.

(2)Yuqing Tong, Jianping Xue, Qizhang Li*, Lei Zhang*. A generalist regulator: MYB transcription factors regulate the biosynthesis of active compounds in medicinal plants. Journal of Experimental Botany. 2024.

(3)张宏*, 李奇璋, 刘爱芬, 曾克武, 丁显廷, 王博谦, 史建伍, 王成牛, 辛海量, 张磊*. 基于成分配伍的中药复方研究策略. 中国科学: 生命科学. 2024, 54.

(4)Qi-Zhang Li^#, Yu-Ying Chen^#, Qiu-Ping Liu, Zhi-Hui Feng, Lei Zhang*, Hong Zhang*. Cucurbitacin B suppresses hepatocellular carcinoma progression through inducing deoxyribonucleic acid (DNA) damage-dependent cell cycle arrest. Phytomedicine. 2024, 126: 155177.

(5)Yi-Qing Deng^#, Min Gao^#, Dong Lu^#, Qiu-Ping Liu, Run-Jing Zhang, Ji Ye, Jing Zhao, Zhi-Hui Feng, Qi-Zhang Li*, Hong Zhang*. Compound-composed Chinese medicine of Huachansu triggers apoptosis of gastric cancer cells through increase of reactive oxygen species levels and suppression of proteasome activities. Phytomedicine. 2024, 123: 155169.

(6)Shang Guo, Nannan Qin, Xiuying Wang, Zanwen Zuo, Qizhang Li*, Yuliang Wang*. Freeze-dried powder of daylily bud improves bromocriptine-induced lactation disorder in rats via JAK2/STAT5 pathway. Journal of Ethnopharmacology. 2023, 313: 116536.

(7)Zanwen Zuo, Zerong Zhou, Yuzhou Chang, Yan Liu*, Yuping Shen*, Qizhang Li*, Lei Zhang*. Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer. Genes & Diseases. 2024, 11(1): 218–233. 高被引论文

(8)Qizhang Li*, Zerong Zhou, Cuiyu Hu, Xianbin Li, Yuzhou Chang, Yan Liu, Yuliang Wang*, Xuanwei Zhou*. Recent advances of bioactive proteins/polypeptides in the treatment of breast cancer. Food Science and Biotechnology. 2023, 32(3):265–282.

(9)Qin Wu, Zhijian Guo, Zerong Zhou, Mengyuan Jin, Qizhang Li*, Xuanwei Zhou*. Recent advances in bioactive peptides from cereal-derived Foodstuffs. International Journal of Food Sciences and Nutrition. 2022, 73(7): 875–888.

(10)Qizhang Li*, Zanwen Zuo, Yan Liu. Recent status of sesaminol and its glucosides: Synthesis, metabolism, and biological activities. Critical Reviews in Food Science and Nutrition. 2022, 12:1–14.

(11)Qizhang Li*, Zanwen Zuo, Zerong Zhou, Yan Ji. Polyamine homeostasis-based strategies for cancer: The role of combination regimens. European Journal of Pharmacology. 2021, 910:174456.

(12)Yan Liu, Qizhang Li, Liudingji Li, Xuan-Wei Zhou*. Immunostimulatory effects of the intracellular polysaccharides isolated from liquid culture of Ophiocordyceps sinensis (Ascomycetes) on RAW264.7 cells via the MAPK and PI3K/Akt signaling pathways. Journal of Ethnopharmacology. 2021, 275:114130.

(13)Qizhang Li^#, Xin Chen^#, Peiwen Mao, Mengyuan Jin, Qin Wu, Xuanwei Zhou*. N-Glycosylated Ganoderma lucidum immunomodulatory protein improved anti-inflammatory activity via inhibition of p38 MAPK pathway. Food & Function. 2021, 12(8): 3393–3404. 封底论文

(14)Qizhang Li^#, Zhiying Wang^#, Qiang Zheng, Sen Liu*. Potential clinical drugs as covalent inhibitors of the priming proteases of the spike protein of SARS-CoV-2. Computational and Structural Biotechnology Journal. 2020, 18: 2200–2208.

(15)Kedi Shao, Peiwen Mao, Qizhang Li, Liudingji Li, Yuliang Wang, Xuanwei Zhou*. Characterization of a novel fungal immunomodulatory protein, FIP-SJ75 shuffled from Ganoderma lucidum, Flammulina velutipes and Volvariella volvacea. Food and Agricultural Immunology. 2019, 30(1): 1253–1270.

(16)Yuzhang Zheng, Qizhang Li, Kedi Shao, Peiwen Mao, Yan Liu, Xuanwei Zhou*. Expression of Ganoderma lucidum fungal immunomodulatory protein (FIP-glu) in Saccharomyces cerevisiae and its immunoreactivity. International Journal of Agriculture and Biology. 2019, 22(2): 369–374.

(17)Qizhang Li, Yuzhou Chang, Zhumei He*, Lei Chen*, Xuanwei Zhou*. Immunomodulatory activity of Ganoderma lucidum immunomodulatory protein via PI3K/Akt and MAPK signaling pathways in RAW264.7 cells. Journal of Cellular Physiology. 2019, 234(12): 23337–23348.

(18)刘玲, 李奇璋, 周选围*, 王玉亮*. 重组黑芝免疫调节蛋白对小鼠巨噬细胞RAW264.7向M1型分化的影响. 食品科学. 2019, 40(23): 170–175.

(19)Qizhang Li, Yuzhang Zheng, Xuanwei Zhou*. Fungal immunomodulatory proteins: characteristic, potential antitumor activities and their molecular mechanisms. Drug Discovery Today. 2019, 24(1): 307–314.

专利：

(1)周选围, 胡大卫, 徐伟民, 李奇璋. N-糖基化修饰之灵芝免疫调节蛋白的应用. ZL 2020 1 1523442.6.

(2)周选围, 王雪飞, 李奇璋, 苏恺琪, 丛蔚然. 灵芝属间的重组真菌免疫调节蛋白基因、该基因编码的蛋白及其应用. ZL 2011 1 0068813.0.

(3)周选围, 王雪飞, 李奇璋, 苏恺琪, 丛蔚然. 灵芝属内重组的真菌免疫调节蛋白基因、该基因编码的蛋白及其应用. ZL 2011 1 0068761.7.

(4)李奇璋, 周选围. 真菌免疫调节蛋白基因启动子、重组载体及宿主细胞. ZL 2009 1 0309882.9.

(5)周选围, 林娟, 李奇璋, 尹燡周, 唐克轩. 利用特异基因序列鉴别药用灵芝的检测方法. ZL 2007 1 0170772.X.