李奇璋讲师

姓名：李奇璋

单位：淮北师范大学 生命科学学院

职称：讲师

学历：博士

E-mail：qizhang-li@hotmail.com；liqzh@chnu.edu.cn

实验室聚焦生物大分子的作用机制，致力于多功能分子设计。目前主要围绕生物活性蛋白的发现与功能研究，开展“机制驱动的AI辅助资源创新”研究。

个人简介：

淮北师范大学创新药物研发中心执行主任；中华中医药学会会员，中国微生物学会会员，湖北省生化学会理事，西安营养学会理事；公共营养师（一级）；基因健康管理师（中级）。《中草药》青年编委；《International Journal of Pharmacology》青年编委；Brit J Pharmacol、Appl Microbiol Biot、Front Plant Sci、Front Immunol、Front Nutr等杂志审稿人。主要从事机制驱动的AI辅助天然产物资源创新与新药创制的研究工作。在学术期刊发表论文50余篇；以第一/通讯作者在Crit Rev Food Sci、Food Funct、Phytomedicine等TOP期刊发表SCI论文20篇；专利授权5项。CNKI中国优秀硕士学位论文全文数据库收录。主持安徽高校科学研究项目1项，湖北省教育厅科研计划项目1项，横向课题2项，参与国家自然科学基金面上项目、上海市科委应用技术开发专项基金、上海市科委支撑项目、上海良友基团等多个项目。指导硕士研究生获得国家奖学金1人、校级优秀毕业生1人；指导本科生多次获得全国大学生生命科学竞赛一等奖、三等奖等。

近五年科研论文：

(1)Zhi-Hui Feng, Wen-Yue Li, Qi-Zhang Li, Feng-Bo Zhao, Hai-Jun Zhang, Lei Zhang*, Hong Zhang**. Tylophora yunnanensis extract inhibits cholesterol biosynthesis to suppress triple negative breast cancer. Journal of Ethnopharmacology. 2025, 348: 119877.

(2)Haizheng Yu^#, Fen Lan^#, Yuan Zhuang^#, Qizhang Li^#, Lianqing Zhang^#, Hongchang Tian, Xiao Bu, Ruibing Chen, Yingying Gao, Zhuo Wang*, Lei Zhang*. Paclitaxel anti-cancer therapeutics: From discovery to clinical use. Chinese Journal of Natural Medicines. 2025, 23: 769-789.

(3)Zanwen Zuo^#, Ruihua Wen^#, Shuang Jing, Xianghui Chen, Ruisang Liu, Jianping Xue, Lei Zhang*, Qizhang Li*. Ganoderma lucidum (Curtis) P. Karst. immunomodulatory protein has the potential to improve the prognosis of breast cancer through the regulation of key prognosis-related genes. Pharmaceuticals. 2024, 17: 1695.

(4)Xianghui Chen, Zanwen Zuo, Xianbin Li, Qizhang Li*, Lei Zhang*. Identification of a potential PGK1 inhibitor with the suppression of breast cancer cells using virtual screening and molecular docking. Pharmaceuticals. 2024, 17: 1636.

(5)李雷, 史建伍, 刘兰玉, 李奇璋, 吴宇, 于海征, 张汉明, 张磊*. 基于指纹图谱和化学计量学研究沪地龙基原间质量差异. 中草药. 2024, 55(21): 7462–7473.

(6)李雷, 史建伍, 李奇璋, 吴宇, 李耀昕, 张汉明, 张磊*. 沪地龙 COI条形码和特征序列鉴定. 中国现代中药. 2024, 26(10): 1654–1662.

(7)李雷, 李奇璋, 张汉明, 张磊*. 沪地龙3个基原的多重位点特异性 PCR 鉴别. 中草药. 2024, 55(16): 5619–5626.

(8)Xianbin Li*, Xiangzhen Zan, Tao Liu, Xiwei Dong, Haqi Zhang, Qizhang Li, Zhenshen Bao, Jie Lin*. Integrated edge information and pathway topology for drug-disease associations. iScience. 2024, 27, 110025.

(9)Yuqing Tong, Jianping Xue, Qizhang Li*, Lei Zhang*. A generalist regulator: MYB transcription factors regulate the biosynthesis of active compounds in medicinal plants. Journal of Experimental Botany. 2024, 75(16): 4729–4744.

(10)Yan Liu, Jiayi Yang, Zhijian Guo, Qizhang Li, Lida Zhang, Lingxia Zhao*, Xuanwei Zhou*. Immunomodulatory Effect of Cordyceps militaris Polysaccharide on RAW 264.7 Macrophages by Regulating MAPK Signaling Pathways. Molecules. 2024, 29(14): 3408.

(11)张宏*, 李奇璋, 刘爱芬, 曾克武, 丁显廷, 王博谦, 史建伍, 王成牛, 辛海量, 张磊*. 基于成分配伍的中药复方研究策略. 中国科学: 生命科学. 2024, 54.

(12)Qi-Zhang Li^#, Yu-Ying Chen^#, Qiu-Ping Liu, Zhi-Hui Feng, Lei Zhang*, Hong Zhang*. Cucurbitacin B suppresses hepatocellular carcinoma progression through inducing deoxyribonucleic acid (DNA) damage-dependent cell cycle arrest. Phytomedicine. 2024, 126: 155177.

(13)Zhi-Hui Feng^#, Shuang Jing^#, Yu-Ping Shen^#, Yu-Qing Tong, Cheng-Jie Xiao, Jian-Ping Xue, Hong Zhang, Qi-Zhang Li*, Lei Zhang*. Advances and perspectives in chemical and biological studies of Baphicacanthus cusia: A focus on antitumor constituents. Medicinal Plant Biology. 2024, 3: e001.

(14)Yi-Qing Deng^#, Min Gao^#, Dong Lu^#, Qiu-Ping Liu, Run-Jing Zhang, Ji Ye, Jing Zhao, Zhi-Hui Feng, Qi-Zhang Li*, Hong Zhang*. Compound-composed Chinese medicine of Huachansu triggers apoptosis of gastric cancer cells through increase of reactive oxygen species levels and suppression of proteasome activities. Phytomedicine. 2024, 123: 155169.

(15)Shang Guo, Nannan Qin, Xiuying Wang, Zanwen Zuo, Qizhang Li*, Yuliang Wang*. Freeze-dried powder of daylily bud improves bromocriptine-induced lactation disorder in rats via JAK2/STAT5 pathway. Journal of Ethnopharmacology. 2023, 313: 116536.

(16)Zanwen Zuo, Zerong Zhou, Yuzhou Chang, Yan Liu*, Yuping Shen*, Qizhang Li*, Lei Zhang*. Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer. Genes & Diseases. 2024, 11(1): 218–233.

(17)Qizhang Li*, Zerong Zhou, Cuiyu Hu, Xianbin Li, Yuzhou Chang, Yan Liu, Yuliang Wang*, Xuanwei Zhou*. Recent advances of bioactive proteins/polypeptides in the treatment of breast cancer. Food Science and Biotechnology. 2023, 32(3):265–282.

(18)Qin Wu, Zhijian Guo, Zerong Zhou, Mengyuan Jin, Qizhang Li*, Xuanwei Zhou*. Recent advances in bioactive peptides from cereal-derived Foodstuffs. International Journal of Food Sciences and Nutrition. 2022, 73(7): 875–888.

(19)Qizhang Li*, Zanwen Zuo, Yan Liu. Recent status of sesaminol and its glucosides: Synthesis, metabolism, and biological activities. Critical Reviews in Food Science and Nutrition. 2022, 12:1–14.

(20)Qizhang Li*, Zanwen Zuo, Zerong Zhou, Yan Ji. Polyamine homeostasis-based strategies for cancer: The role of combination regimens. European Journal of Pharmacology. 2021, 910:174456.

(21)Yan Liu, Qizhang Li, Liudingji Li, Xuan-Wei Zhou*. Immunostimulatory effects of the intracellular polysaccharides isolated from liquid culture of Ophiocordyceps sinensis (Ascomycetes) on RAW264.7 cells via the MAPK and PI3K/Akt signaling pathways. Journal of Ethnopharmacology. 2021, 275:114130.

(22)Hongyan Ma, Qizhang Li, Jing Wang, Jing Pan, Zhengding Su, Sen Liu*. Dual inhibition of ornithine decarboxylase and A1 adenosine receptor efficiently suppresses breast tumor cells. Frontiers in Oncology. 2021, 11: 636373.

(23)Qizhang Li^#, Xin Chen^#, Peiwen Mao, Mengyuan Jin, Qin Wu, Xuanwei Zhou*. N-Glycosylated Ganoderma lucidum immunomodulatory protein improved anti-inflammatory activity via inhibition of p38 MAPK pathway. Food & Function. 2021, 12(8): 3393–3404.

专利：

(1)李奇璋, 闻瑞花, 朱雅, 杨晨. 一种灵芝免疫调节蛋白在制备用于靶向TK1与RRM2相互作用的产品中的应用. 申请号：2026102298997. 申请日：2026年02月26日.

(2)李奇璋, 左赞文, 钱晓轩, 王子晗. 一种灵芝免疫调节蛋白在制备用于靶向TK1的产品中的应用. 申请号：2026102296065. 申请日：2026年02月26日.

(3)李奇璋, 左赞文, 潘心悦, 张倩. 灵芝免疫调节蛋白在制备抗乳腺癌药物中的用途. 申请号：2026102287070. 申请日：2026年02月26日.

(4)周选围, 胡大卫, 徐伟民, 李奇璋. N-糖基化修饰之灵芝免疫调节蛋白的应用. ZL 2020 1 1523442.6.

(5)周选围, 王雪飞, 李奇璋, 苏恺琪, 丛蔚然. 灵芝属间的重组真菌免疫调节蛋白基因、该基因编码的蛋白及其应用. ZL 2011 1 0068813.0.

(6)周选围, 王雪飞, 李奇璋, 苏恺琪, 丛蔚然. 灵芝属内重组的真菌免疫调节蛋白基因、该基因编码的蛋白及其应用. ZL 2011 1 0068761.7.

(7)李奇璋, 周选围. 真菌免疫调节蛋白基因启动子、重组载体及宿主细胞. ZL 2009 1 0309882.9.

(8)周选围, 林娟, 李奇璋, 尹燡周, 唐克轩. 利用特异基因序列鉴别药用灵芝的检测方法. ZL 2007 1 0170772.X.